Patterns in blood pressure medication use in US incident dialysis patients...
AbstractBackgroundSeveral observational studies have evaluated the effect of a single exposure window with blood pressure (BP) medications on outcomes in incident dialysis patients, but whether BP...
View ArticleTrends in anemia management in US hemodialysis patients 2004–2010
AbstractBackgroundThere have been major changes in the management of anemia in US hemodialysis patients in recent years. We sought to determine the influence of clinical trial results, safety...
View ArticleSemicompeting risks in aging research: methods, issues and needs
AbstractA semicompeting risks problem involves two-types of events: a nonterminal and a terminal event (death). Typically, the nonterminal event is the focus of the study, but the terminal event can...
View ArticleAssociation of mitochondrial DNA levels with frailty and all-cause mortality
AbstractMitochondrial function is altered with age and variants in mitochondrial DNA (mtDNA) modulate risk for several age-related disease states. However, the association of mtDNA copy number, a...
View ArticleFrailty: a tale of two concepts
AbstractFrailty is increasingly relevant for clinicians to improve care for vulnerable older adults. Prominent frailty measures include the frailty phenotype and the frailty index. The frailty...
View ArticleThe Role of Religious Involvement in the Relationship Between Early Trauma...
AbstractThe purpose of this study was to determine the role of religious involvement and related indicators - religious coping, intrinsic religiosity, forgiveness and gratitude - in reducing the...
View ArticleThe Internalized Homophobia Scale for Vietnamese Sexual Minority Women:...
AbstractWe developed the first Vietnamese Internalized Homophobia (IH) scale for use with Vietnamese sexual minority women (SMW). Drawing from existing IH scales in the international literature and...
View ArticleAnxiety disorders and all-cause mortality: systematic review and meta-analysis
AbstractPurposeThe purpose of this study was to perform a systematic review and meta-analysis of prospective cohort studies that examined the relationship between anxiety disorders, or clinically...
View ArticleStandard set of health outcome measures for older persons
AbstractBackgroundThe International Consortium for Health Outcomes Measurement (ICHOM) was founded in 2012 to propose consensus-based measurement tools and documentation for different conditions and...
View ArticleA Robust Characterization of Inflamm-Aging and Other Immune Processes Through...
AbstractChronic low-grade inflammation has long been considered an important part of the aging process (“inflamm-aging”). However, measurement of this process is highly variable across studies, often...
View ArticleParametric estimation of association in bivariate failure-time data subject...
AbstractThere has arisen a considerable body of research addressing the estimation of association between paired failure times in the presence of competing risks. In a 2002 paper, Bandeen-Roche and...
View ArticleA Robust Characterization of Inflamm-aging and Other Immune Processes Through...
AbstractChronic low-grade inflammation has long been considered an important part of the aging process (“inflamm-aging”). However, measurement of this process is highly variable across studies, often...
View ArticleEvidence from two cohorts for the frailty syndrome as an emergent state of...
AbstractFrailty is a clinical syndrome often present in older adults and characterized by a heightened vulnerability to stressors. The biological antecedents and etiology of frailty are unclear despite...
View ArticleAgreement between standard and self-reported assessments of physical frailty...
AbstractBackgroundThe ability to identify frail older adults using a self-reported version of the physical frailty phenotype (PFP) that has been validated with the standard PFP could facilitate...
View ArticleClinical trial participation predicts improved survival in older adults...
AbstractBackgroundOlder adults represent a large oncologic demographic and are under-represented within oncology research despite constituting nearly two-thirds of the oncologic population in the...
View ArticleSubstitution of self-reported measures for objectively assessed grip strength...
AbstractBackgroundFrailty assessment promises to identify older adults at risk for adverse consequences following stressors and target interventions to improve health outcomes. The Physical Frailty...
View ArticleThe physical frailty syndrome as a transition from homeostatic symphony to...
AbstractFrailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the...
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